Korean Journal of Community Nutrition

Research Article

[English]
Micronutrients and prevention of cervical pre-cancer in HPV vaccinated women: a cross-sectional study: Chandrika J Piyathilake, Suguna Badiga, Nongnut Thao, Pauline E Jolly; Korean J Community Nutr 2023;28(1):61-73. Published online February 28, 2023; DOI: https://doi.org/10.5720/kjcn.2023.28.1.61

Objectives
Prophylactic vaccines against high-risk human papillomaviruses (HR-HPVs) hold promise to prevent the development of higher grade cervical intraepithelial neoplasia (CIN 2+) and cervical cancer (CC) that develop due to HR-HPV genotypes that are included in HPV vaccines, but women will continue to develop CIN 2+ and CC due to HR-HPV genotypes that are not included in the quadrivalent HPV vaccine (qHPV) and 9-valent HPV vaccine (9VHPV). Thus, the current vaccines are likely to decrease but not entirely prevent the development of CIN 2+ or CC. The purpose of the study was to determine the prevalence and determinants of CIN 2+ that develop due to HR-HPVs not included in vaccines.
Methods
Study population consisted of 1476 women tested for 37 HPVs and known to be negative for qHPVs (6/11/16/18, group A, n = 811) or 9VHPVs (6/11/16/18/31/33/45/52/58, group B, n = 331), but positive for other HR-HPVs. Regression models were used to determine the association between plasma concentrations of micronutrients, socio-demographic, lifestyle factors and risk of CIN 2+ due to HR-HPVs that are not included in vaccines.
Results
The prevalence of infections with HPV 31, 33, 35 and 58 that contributed to CIN 2+ differed by race. In group A, African American (AA) women and current smokers were more likely to have CIN 2 (OR = 1.76, P = 0.032 and 1.79, P = 0.016, respectively) while in both groups of A and B, those with higher vitamin B12 were less likely to have similar lesions (OR = 0.62, P = 0.036 and 0.45, P = 0.035, respectively).
Conclusions
We identified vitamin B12 status and smoking as independent modifiable factors and ethnicity as a factor that needs attention to reduce the risk of developing CIN 2+ in the post vaccination era. Continuation of tailored screening programs combined with non-vaccine-based approaches are needed to manage the residual risk of developing HPVrelated CIN 2+ and CC in vaccinated women.

Citations

Citations to this article as recorded by

The Relationship Between Metal Exposure and HPV Infection: Evidence from Explainable Machine Learning Methods
Huangyu Hu, Yue Wu, Jiaqi Liu, Min Zhao, Ping Xie
Biological Trace Element Research.2025; 203(4): 2206. CrossRef
The Impact of an Educational Program on Cervical Cancer Knowledge Among HIV-Positive Women in Bali, Indonesia
Desak Lestari, Ania Wellere, Ilene Brill, Ni Luh Sari, Pauline Jolly, Chandrika Piyathilake
International Journal of Women's Health.2024; Volume 16: 1677. CrossRef

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Original Article

[English]
Selenium, Manganese, Copper and Zinc Contents in Serum of Patients with Cervical Intraepithelial Neoplasia: Hyun Sook Bae, Geum Ju Lee, Hong Seok Ahn; Korean J Community Nutr 2005;10(5):700-707. Published online October 31, 2005

Abstract PDF: The purpose of this study was to investigate the implications of dietary intake and the level of serum micronutrients (Se, Mn, Cu, Zn), lipid peroxidation, and antioxidant capacity in Korean women with cervical intraepithelial neoplasia (CIN). From October 2002 to March 2003, 50 patients diagnosed with CIN (confirmed with colposcopy directed biopsy) and 50 patients without any cervical disease as the control group were enrolled in the study at the Department of Gynecology Cancer Center at Samsung Cheil Hospital. Animal fat intake in CIN group was significantly higher than that of the control group, but plant protein intake in the CIN group was significantly lower than that of the Control group. Energy and zink intakes were similar in the two groups. The serum concentration of antioxidant minerals in the CIN group were not signifi-cantly different from the control group. The total radical trapping antioxidant potential concentration of plasma was sig-nificantly lower in the CIN group (1.12 mM) than in the control group (1.25 mM)(p < 0.05). But MDA (malondialde-hyde) of serum was significantly higher in the CIN group (7.60 mM) than in the control group (4.99 mM)(p < 0.005). The serum selenium concentration of the control group showed significant positive correlation with the MDA level (r = 0.311). These findings are suggestive of protective roles for healthy dietary habit including increasing antioxidant nut-rients and decreasing intake of fat.

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